Nestled within the vaulted ceilings of Portrait Milano, The Longevity Spa redefines rest as a powerful ritual of regeneration. For visitors from around the world, it offers a return to equilibrium, where advanced medical-grade biohacking meets the comforting embrace of holistic care.

“We wanted to create a place where transformation is measurable, where cutting-edge science meets holistic care in a way that feels deeply personal,” says Luigi Caterino, Co-Founder of The Longevity Spa. “A one-stop destination for those who want to live longer - but above all, live better.”

Inspired by the world’s longest-living regions, the Spa’s Signature Rituals transport guests on a sensory journey where touch, scent and sound slow time. From the Pura Vida Ritual from Costa Rica to detoxify and lighten the body and spirit, to the Iki-Sabi Ritual inspired by Okinawa’s philosophy of purposeful living, each treatment guides guests towards deep relaxation, wrapped within the secrets of longevity.

Guests arriving in Milan can step into the Cryosuite Total Body chamber, experiencing temperatures of -85°C to -95°C that activate melatonin production, boost circulation and trigger neuro-metabolic renewal. The Ultimate Biohacking protocol, combining Dry Float Therapy, Near Infrared Total Body Light and Hydrogen-Oxygen Therapy, further resets the circadian rhythm, reduces inflammation and promotes restorative sleep, transforming the fatigue of travel into an opportunity for regeneration.

To build a personalized treatment plan, guests may opt for the Complete Longevity Check-Up, a detailed DNA analysis across over 130 genes related to diet, skin ageing and sports performance, alongside tests for inflammation and oxidative stress. This data-driven approach enables the design of custom protocols that incorporate targeted treatments, movement, mindfulness and nutrition, guiding guests toward sustainable wellness built around their individual needs and goals.

The Spa’s curated Longevity Experiences, such as the Energy Boost or Skin Glow treatments, blend advanced technologies with targeted therapies to revitalize body and mind. The Gym, open 24/7 to hotel guests, redefines physical activity, using Biostrength circuits and Technogym’s digital personalization to deliver 30% more results within the same time. Here, fitness aligns with circadian health for those who wish to maintain peak performance while travelling.

Tailor-made Longevity Programs, such as the 3- or 6-day Sleep Better Program, offer a complete reset in case of insomnia, burnout or chronic fatigue. Through diagnostics, supplementation, mindfulness, fitness and massage, these programs help restore vitality and rewire the body for better, longer-lasting sleep.

The Longevity Suite’s biohacking philosophy, built on the pillars of controlled cold exposure, photobiomodulation, intermittent fasting and mindfulness, is integrated throughout the guest journey. Treatments are designed to optimize cellular health, reduce inflammation and enhance mental clarity, whether guests are in Milan for business, leisure or simply to pause.

Guests can also indulge in advanced face treatments featuring Dr. Barbara Sturm’s molecular science formulations, body sculpting and detox rituals, or massages such as the Deep Blue, designed specifically to restore restful sleep and ease the stresses of travel. Alternatively, the pool and wet area, set beneath vaulted ceilings resting on granite columns, offers a majestic environment for a multi-sensory experience.

The Longevity Suite has become Europe’s benchmark for medical-grade wellness, rooted in science and the lifestyle practices of the world’s healthiest communities. Guests of Portrait Milano can now turn their visit into a profound journey of renewal, where travel turns into a pathway to better living.